Custom Antibody Production
QYAOBIO provides custom antibody production for customers in worldwide
Custom antibody production involves the entire process of producing an antibody with specificity to a specific biological target. It mainly includes the following steps:
- Antigen design
- Immunization
- Antibody collection
- Antibody screening
- Antibody isotyping
- Antibody purification
Qyaobio is committed to provide scientific research institutions and pharmaceutical companies with one-stop custom antibody production services, from antigen design through to custom antibody generation. To support the advancement of your study, our custom antibodies team can provide highly specific and high-quality products designed just for you.
Custom Antibody Services
Custom Monoclonal Antibody Production
Monoclonal antibodies are an excellent option if you require homogenous material that is consistent over an extended period of time. Qyaobio can support you through research and into development, customizing our packages to meet your requirements. We are glad to offer monoclonal antibody production services using traditional hybridoma-based technology. Our custom antibody production services team can generate monoclonal antibodies in a variety of species, such as mouse and rabbit.
Custom Polyclonal Antibody Production
Qyaobio has been providing high-quality polyclonal antibodies to biopharmaceutical, diagnostic and academic scientists for many years. We have the extensive expertise to effectively drive your custom polyclonal antibody production projects to successful completion. We provide one-stop solutions for your custom polyclonal antibody production, taking your project all the way from antigen design, peptide synthesis, and animal immunization to antibody purification and QC with ELISA test, with antibodies produced in mouse, rat, rabbit, SPF animals, and other species.
Custom Recombinant Antibody Production
Compared to purified natural and classical hybridoma antibodies, recombinant antibodies have numerous advantages, which include supply chain security and improved quality control in production. Whether your antibody is derived from an existing hybridoma cell line, is already a purified antibody protein, or is generated from an antibody display library, Qyaobio can utilize our expertise to quickly convert your antibody to a recombinant antibody or modify or engineer your critical antibody to meet your needs. We enhance expression and yield relative to a hybridoma using our proprietary expression systems and modification libraries, preventing lengthy batch-to-batch bridging studies and allowing you to get the data needed to move your project forward.
Custom Pairing Antibody Production
Paired antibodies can bind to the same antigen at the same time. They are commonly applied in double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Whether creating a monoclonal antibody pair, a polyclonal antibody pair, or a combination, Qyaobio’s years of expertise in developing antibody pairs is at your disposal. Although matching to an existing antibody can be made, it is recommended to generate antibody pairs concurrently so that the optimal antibody combination can be found empirically for every application. When you need in the future, you’ll save time, money, and effort by generating antibody pairs together from the start. We work closely with customers to provide satisfaction in any application.
Custom Antibody Purification Services
Purification of antigen-specific antibodies differs depending on antibody clonality (monoclonal or polyclonal) and the method used to customize the antibody. Using a wide array of protein purification techniques, Qyaobio can purify your monoclonal or polyclonal antibodies in mg-to-gram amounts for use in cGMP diagnostics or research. We can also purify any raw antibodies produced in your lab or from another supplier. Our scientific staff will work with you to determine the best solutions for meeting your goals. Our goal is to create a technique that achieves the optimal balance of yield, purity, and cost.
Consider for Antibody Production
Think about these decisions in relation to the production of antibodies.
Antigen Design
Antigen design is the basic of custom antibody production. There are 4 common ways to design antigens for a protein or peptide biomarker: peptide, recombinant protein, full length proteins or whole cell/tissue lysates. Recombinant protein is generally the best choice, because it has a higher immunogenicity than peptides, and is better than whole proteins or cells/tissues on specificity.
Antibody Discovery Platform
It has mainly 4 common platforms: polyclonal, hybridoma, recombinant, and phage display.
- Cost: polyclonal < hybridoma < recombinant = phage display.
- Application: Polyclonal and hybridoma are good for RUO, while recombinant and phage display are suitable for DX and therapeutic applications.
- More expensive platforms: Antibodies targeting difficult biomarkers, or diagnostics or therapeutics.
- Low cost platforms: Biomarkers that tend to produce antibodies, fast turnaround time.
Host Selection
Rabbit and mouse are common hosts for antibody production. Common hosts for antibody production are rabbit and mouse. In case of multiplexing staining, antibodies from diverse hosts will be required to produce distinct stains of your biomarkers, and you may need to investigate more exotic hosts.
Supplier Selection
Many uncertainties exist when generating antibodies, which can be mitigated through expertise and experience. When it comes to supplier selection, pick the ones with most experience with your particular application is critical to success. During your initial contacts with potential vendors, look for those who demonstrate a customer service-focused culture and good communication habits.
Competitive Custom-Antibody Service
Qyaobio is specialized in antibody discovery&development, and harbors extensive experience in antibody generation using our comprehensive platform. Our offers comprehensive solutions for the generation of custom antibodies. Our experienced team will work with you from antigen design to antibody purification and validation. We offer several comprehensive antibody discovery platforms, including hybridoma, phage display, and single B-cell technologies.
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