Cathepsin G

Cathepsin G is a protein in humans with encode of the CTSG gene, it is one of the serine proteases of the chymotrypsin family. Cathepsin G is also a member of the peptidase S1 protein family, it is stored in the azurophil granules. It plays an critical roles in remodeling of tissue in injury or wound.

Cathepsin G has the critical role in blood clotting, as it can inactivate several clotting factors. It also can inhibit several bacteria growth, like E.coli, P.aeruginosa and S.aureus. Gathepsin G also has other potential substrates and activities:

• Conversion of angiotensin I to angiotensin II
• Activation and damage of cultured airway epithelial cells
• Stimulation of secretion by airway gland serous cells
• Induction of transendothelial albumin flux
• Processing of NF-kB (p65) in vitro