Protease Activated Receptor Peptide

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Protease activated receptors (PAR) are a subfamily of related G protein-coupled receptors, which are activated by cleavage of the extracellular domain. PARs are highly expressed in platelets, and in endothelial cells, fibroblasts, immune cells, myocytes, neurons. Protease, as the important regulators of cell behavior, survival and apoptosis, communicate to cells directly thorough PARs. Further, the termination and regulation of PAR signaling by endocytosis are currently available pharmacologic approaches.

Each PAR has different protease specificities, expression patterns, and functions in a various range of tissues and cell types. There are four mammalian members of the protease-activated receptor (PAR) family:

  • PAR1- (encoded by the gene F2R)
  • PAR2 – (encoded by the gene F2RL1)
  • PAR3 – (encoded by the gene F2RL2)
  • PAR4 – (encoded by the gene F2RL3)

Notice: All peptides are only for research purposes, Not for clinical use.

PAR Peptides

1.[Phe1,Ser2,Tyr6]-Protease Activated Receptor-1 (1-6) amide, human
  • Name: [Phe1,Ser2,Tyr6]-Protease Activated Receptor-1 (1-6) amide, human
  • Sequence: FSLLRY-NH2
  • CAS Number: [245329-02-6]
  • Formula: C39H60N10O8
  • Characteristics: None
  • Reference: B.Al-Ani et al., J. Pharmacol. Exp. Ther., 300, 702 (2002)  S.Wilson et al., Biochem. J., 388, 967 (2005)
2.PAR-2 (1-6),Protease Activated Receptor-2 (1-6), (mouse, rat)
  • Name: PAR-2 (1-6),Protease Activated Receptor-2 (1-6), (mouse, rat)
  • Sequence: SLIGRL
  • CAS Number: [164081-25-8]
  • Formula: C29H55N9O8
  • Characteristics: None
  • Reference: R.J.Santulli et al., Proc. Natl. Acad. Sci. USA, 92, 9151 (1995)  A. Bhattacharya et al., J. Pharmacol. Exp. Ther., 297, 573 (2001)
3.PAR-2 (1-6),Protease Activated Receptor-2 (1-6),amide (mouse, rat)
  • Name: PAR-2 (1-6),Protease Activated Receptor-2 (1-6),amide (mouse, rat)
  • Sequence: SLIGRL-NH2
  • CAS Number: [171436-38-7]
  • Formula: C29H56N10O7
  • Characteristics: None
  • Reference: B.Al-Ani et al., Br. J. Pharmacol., 128, 1105 (1999)  E.R.Sharlow et al., J. Cell Sci., 113, 3093 (2000)
4.[Ala1]-Protease Activated Receptor-4(Ala1)-PAR-4 (1-6)) (mouse)
  • Name: [Ala1]-Protease Activated Receptor-4|(Ala1)-PAR-4 (1-6) (mouse)
  • Sequence: AYPGKF
  • CAS Number: [380900-00-5]
  • Formula: C34H47N7O8
  • Characteristics: None
  • Reference: D.Woulfe et al., J. Clin. Invest., 113, 441 (2004)  E.A. Lidington, et al., Am J Physiol Cell Physiol, 289, C1437 (2005)
5.PAR-4 (1-6)) amide Protease Activated Receptor-4 (1-6) amide, mouse
  • Name: PAR-4 (1-6) amide |Protease Activated Receptor-4 (1-6) amide, mouse
  • Sequence: GYPGKF-NH2
  • CAS Number: [245443-52-1]
  • Formula: C33H46N8O7
  • Characteristics: None
  • Reference: Fang, J. et al. Blood 106, 2671(2005)  Mulè, F. et al. Gut. 53, 229 (2004)
6.(Ala1)-PAR-4 (1-6)) amide (mouse)[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse
  • Name: (Ala1)-PAR-4 (1-6) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse
  • Sequence: AYPGKF-NH2
  • CAS Number: [352017-71-1]
  • Formula: C34H48N8O7
  • Characteristics: None
  • Reference: Sabri, A. et al. J. Biol. Chem. 278, 11714 (2003)  Ma, L. et al. Proc. Natl. Acad. Sci. USA 102, 216 (2005)
7.Protease Activated Receptor-2 (1-6), human
  • Name: Protease Activated Receptor-2 (1-6), human
  • Sequence: SLIGKV
  • CAS Number: [202933-49-1]
  • Formula: C28H53N7O8
  • Characteristics: None
  • Reference: None
8.Protease Activated Receptor-2 (6-1) amide, human
  • Name: Protease Activated Receptor-2 (6-1) amide, human
  • Sequence: VKGILS-NH2
  • CAS Number: [245329-01-5]
  • Formula: C28H54N8O7
  • Characteristics: None
  • Reference: None
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